Alveolar macrophages help CD8+ T cells go (anti-)viral

The human immune system is a highly complex network of cells, signals, and responses that is tightly regulated to ensure that the body can fight off infection without damaging its own tissues. Now, researchers from Japan report a new way in which the immune system protects lung tissue from viral infections.

Pathogen involvement in bone marrow failure (BMF). Primary viral or

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Migration of CD8 T-cell subsets during chronic viral infection. Both

CD8+ T cell activation in cancer comprises an initial activation phase in lymph nodes followed by effector differentiation within the tumor - ScienceDirect

Research outcomes

In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer - ScienceDirect

Influenza-trained mucosal-resident alveolar macrophages confer long-term antitumor immunity in the lungs

The effects of SARS-CoV-2 infection on modulating innate immunity and strategies of combating inflammatory response for COVID-19 therapy, Journal of Biomedical Science

Pathogens, Free Full-Text